Penn Researchers Find Yeast May Hold Clue to Aging

The single-celled microbes known as yeasts have long served as model systems for the puzzle that is the aging process, and in this week’s issue of Cell Metabolism, they fill in yet another piece.

The study, led by Daniel S. Och University Professor Shelley Berger, identifies a new molecular circuit that controls longevity in yeast and more complex organisms and suggests a therapeutic intervention that could mimic the lifespan-enhancing effect of caloric restriction with no dietary restrictions necessary.  Berger is a Penn Integrates Knowledge Professor who holds dual appointments in the Department of Biology in Penn Arts and Sciences and the Departments of Genetics and Cell and Developmental Biology in the Perelman School of Medicine.

The study involved researchers at Penn, the Wistar Institute, the University of Washington, the Buck Institute for Research on Aging, and the University Medical Center Utrecht. 

The study was supported by the National Institutes of Health and the Ellison Medical Foundation.

Read the full story here.

Arts & Sciences News

University of Pennsylvania, Neubauer Family Foundation, and Philadelphia Police Department Partner to Support Police Leadership Education

The first-of-its-kind graduate degree in the U.S. for police leaders launches this fall at the School of Arts & Sciences.

View Article >
Marisa C. Kozlowski Named Next Associate Dean for the Natural Sciences

Kozlowski, who joined the Penn faculty in 1997, succeeds Mark Trodden, who transitions to the Dean of Penn Arts & Sciences on June 1.

View Article >
One Fourth Year, One Alum Receive 2025 Hertz Fellowship

Eric Tao, C’25, Gr’25 (left), and Suraj Chandran, C’23, were awarded the honor, part of a group of 19 fellows selected this year. Each one receives five years of funding toward a doctoral program.

View Article >
Benjamin Nathans Wins 2025 Pulitzer Prize in General Nonfiction

Nathans, Alan Charles Kors Endowed Term Professor of History, won for his book “To the Success of Our Hopeless Cause: The Many Lives of the Soviet Dissident Movement.”

View Article >
Mark Devlin Elected to National Academy of Sciences

He joins three others from Penn to receive the honor this year, all recognized for “distinguished and continuing achievements in original research.”

View Article >
Michael Jones-Correa and Sophia Rosenfeld Elected to American Academy of Arts & Sciences

They join three others from the University of Pennsylvania, selected as part of the Academy’s mission to convene leaders from “every field of human endeavor to examine new ideas, address issues of importance to the nation and the world, and work together.”

View Article >