Researchers Show That Cubic Membranes Might Defend Sick Cells

It’s well known that, when cells are subject to stress, starvation, or viral infection, they sometimes adopt a cubic architecture. Unlike the simple spherical structure of membranes in healthy cells, these cubic membranes, or cubosomes, are very complex, forming an interconnected network of water channels resembling a “plumber’s nightmare.”

Yet scientists still don’t have a clear understanding of how or why this happens.

“The transition from this very simple spherical structure into a complex cubic one is something that happens once in a while,” Virgil Percec, the P. Roy Vagelos Professor of Chemistry, says. “But we don’t yet have a clear understanding of the mechanism behind it.”

Now, in a paper published in ACS Central Science, researchers at Penn have completed the first experiment able to model these different biological structures. They used these models to figure out how those structures affect the functionality of certain biological systems. By doing this, they were able to demonstrate that cubic membranes in unhealthy cells might be used as a defense mechanism.

Click here to read the full story.

Arts & Sciences News

Hanming Fang Named Inaugural Norman C. Grosman Professor of Economics

An applied microeconomist who integrates rigorous modeling with data analysis, Fang’s research within the field of public economics focuses on health insurance and healthcare markets.

View Article >
Julie Nelson Davis Named Paul F. Miller, Jr. and E. Warren Shafer Miller Professor of History of Art

Davis specializes in the arts and material cultures of 18th- and 19th-century Japan, with a focus on prints, paintings, and illustrated books.

View Article >
Justin Khoury Named Edmund J. and Louise W. Kahn Term Professor of Physics and Astronomy

Khoury’s research interests lie at the intersection of particle physics and cosmology.

View Article >
University of Pennsylvania, Neubauer Family Foundation, and Philadelphia Police Department Partner to Support Police Leadership Education

The first-of-its-kind graduate degree in the U.S. for police leaders launches this fall at the School of Arts & Sciences.

View Article >
Professor of Biology Philip Rea Wins Neal Award for Scientific Journalism

Rea won for the award for Best Technical/Scientific Content for his article “Gliflozins for Diabetes: From Bark to Bench to Bedside,” published in American Scientist.

View Article >
Marisa C. Kozlowski Named Next Associate Dean for the Natural Sciences

Kozlowski, who joined the Penn faculty in 1997, succeeds Mark Trodden, who transitions to the Dean of Penn Arts & Sciences on June 1.

View Article >